Always verify pricing and state availability on the provider's website before signing up.How our reviews work →
MyStart Health vs Synergy Rx
An in-depth comparison of two leading GLP-1 Providers
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
7.7
MyStart Health
Best for fastest compounded GLP-1 onboarding with a price lock★★★★☆3.9
Starting at $299/mo
CompoundedSemaglutideTirzepatidePrice Lock Guarantee
Visit MyStart Health →7.4
Synergy Rx
Best for broadest drug catalog in the Lion MD white-label cluster★★★★☆3.7
Starting at $199/mo
CompoundedBrandSemaglutideTirzepatide
Visit Synergy Rx →Side-by-Side Comparison
| Feature | MyStart Health | Synergy Rx |
|---|---|---|
| Overall Score | ✓7.7/10 | 7.4/10 |
| Starting Price | $299/mo | ✓$199/mo |
| Editorial Rating | ✓3.9 ★ /5 | 3.7 ★ /5 |
| Features | 6 features | 6 features |
| States Available | 0 | 0 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
MyStart Health
Pros
- ✓Price Lock Guarantee — base monthly rate ($299) doesn't increase even when your prescribed dose escalates
- ✓Fast onboarding: quoted 5-minute intake, 24-hour prescription turnaround, 2–4 day shipping
- ✓24/7 access to the care team with unlimited clinician messaging included
- ✓LegitScript certified
- ✓Transparent Section 503A compounding disclosure on every landing page
Cons
- ✗Not BBB accredited — BBB rating of C+ with 10 complaints filed against the business (BBB file opened April 24, 2025), most involving shipping delays and customer service access issues in early 2026
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- ✗Oral tirzepatide referenced in marketing but FAQ clarifies injectable is 'currently more common' — no FDA-approved oral tirzepatide exists, and the November 2025 Chimicles class action against OpenLoop/Triad Rx over unapproved oral tirzepatide products is a cautionary data point for the category
- ✗Very recent company (incorporated May 21, 2024 per BBB) — limited operational track record
- ✗Pharmacy partners not publicly named — no independent way to verify 503A compliance
- ✗Clinical efficacy claims are based on a homepage survey of only 16 self-reporting customers
Synergy Rx
Pros
- ✓Broad drug catalog: compounded sema/tirz in both injection and oral dissolving tablet formats, plus brand-name Ozempic, Wegovy, and Mounjaro
- ✓Claims 50,000+ patients per homepage as of late 2025
- ✓All 50 US states subject to state telehealth regulations
- ✓Same named medical team as Breeze Meds and Care Bare Rx (Dr. Carr and Dr. Tenbrink via Lion MD)
- ✓Four named 503A pharmacy partners (Belmar, Strive, Epiq Scripts, Casa Pharma Rx)
- ✓LegitScript seal displayed in footer
Cons
- ✗Runs on the same Lion MD clinician network and the same 4 compounding pharmacies as Breeze Meds and Care Bare Rx — the three brands are white-labeled storefronts on top of one underlying operation
- ✗Mandatory individual arbitration + class action waiver in ToS (30-day opt-out window from signup)
- ✗Consultation fees are non-refundable and all prescription sales are final per ToS
- ✗Platform explicitly disclaims liability for third-party pharmacy medication quality: 'SynergyRx makes no representations or warranties regarding the efficacy, safety, or outcomes of any medication provided through these third parties'
- ✗State availability is 'subject to each state's telehealth and prescribing regulations' — the full list of active states requires contacting customer service rather than being published
- ✗Do NOT confuse with the unrelated 'Synergy Rx Pharmacy' (San Diego, CA) that issued a voluntary nationwide recall in February 2017 for non-sterile compounded products — that is a different entity in a different state
- ✗Do not visit synergyrx.com — it is a parked domain on Sedo and unrelated to the telehealth brand. The correct domain is synergyrx.co
Our Verdict
Winner: MyStart HealthScore: 7.7/10
MyStart Health edges out Synergy Rx with a higher overall score of 7.7/10 and is particularly strong for fastest compounded GLP-1 onboarding with a price lock. Synergy Rx remains a solid alternative, especially if you're looking for broadest drug catalog in the Lion MD white-label cluster.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.