Actin vs TMates
An in-depth comparison of two leading GLP-1 Providers
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Actin
Best for affordable compounded semaglutide with B12 enhancementStarting at $133/mo
TMates
Best for nationwide compounded GLP-1 availability including Puerto RicoStarting at $199/mo
Side-by-Side Comparison
| Feature | Actin | TMates |
|---|---|---|
| Overall Score | ✓7.0/10 | 6.3/10 |
| Starting Price | ✓$133/mo | $199/mo |
| Editorial Rating | ✓3.5 ★ /5 | 3.2 ★ /5 |
| Features | 2 features | ✓4 features |
| States Available | 0 | 0 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Actin
Pros
- ✓Semaglutide + B12 combination for added energy support
- ✓Transparent pricing — exact cost shown upfront with no hidden fees
- ✓Competitive starting price from $133
Cons
- ✗Semaglutide only — no tirzepatide or liraglutide
- ✗No visible LegitScript or PCAB accreditation
- ✗State availability not disclosed
- ✗Broader platform (hormones, sexual wellness, hair health)
TMates
Pros
- ✓All-inclusive monthly pricing covers medication, consultations, nutrition coaching, and 24/7 support with no separate membership fee
- ✓Available in all 50 US states plus Puerto Rico and other US territories
- ✓Both compounded semaglutide and tirzepatide offered
- ✓Fast stated turnaround (intake to medication delivery in 2–3 days)
Cons
- ✗No disclosed third-party accreditations (no verified LegitScript, PCAB, ACHC, or NABP) — weaker pharmacy-oversight signal than competitors
- ✗BBB rating B+ (not accredited) with 8 complaints filed, most involving billing and cancellation friction
- ✗Trustpilot reviews show partial-refund and contact-difficulty reports, and some customer posts allege reviews have been removed
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- ✗Pharmacy partners not publicly named — TMates explicitly disclaims both medical practice and pharmacy dispensing responsibility, routing both to independent third parties
- ✗Also sells Schedule III testosterone products and other wellness SKUs alongside GLP-1s — worth knowing about for readers who want a GLP-1-focused provider
Our Verdict
Actin edges out TMates with a higher overall score of 7.0/10 and is particularly strong for affordable compounded semaglutide with B12 enhancement. TMates remains a solid alternative, especially if you're looking for nationwide compounded GLP-1 availability including Puerto Rico.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.