Actin vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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Actin
Best for affordable compounded semaglutide with B12 enhancementStarting at $133/mo
NewSelf
Best for lowest-cost compounded GLP-1 with pharmacy quality transparencyStarting at $100/mo
Side-by-Side Comparison
| Feature | Actin | NewSelf |
|---|---|---|
| Overall Score | 7.0/10 | ✓7.8/10 |
| Starting Price | $133/mo | ✓$100/mo |
| Editorial Rating | 3.5 ★ /5 | ✓3.9 ★ /5 |
| Features | 2 features | ✓5 features |
| States Available | 0 | ✓49 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Actin
Pros
- ✓Semaglutide + B12 combination for added energy support
- ✓Transparent pricing — exact cost shown upfront with no hidden fees
- ✓Competitive starting price from $133
Cons
- ✗Semaglutide only — no tirzepatide or liraglutide
- ✗No visible LegitScript or PCAB accreditation
- ✗State availability not disclosed
- ✗Broader platform (hormones, sexual wellness, hair health)
NewSelf
Pros
- ✓Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- ✓All dosages at the same price — no price escalation as dose increases
- ✓LegitScript certified with 503A licensed pharmacies
- ✓Third-party potency, sterility, and endotoxicity testing
- ✓48 states + Puerto Rico coverage
- ✓B12/B6 + Glycine enhanced formulations
- ✓No membership fees
Cons
- ✗Not available in Mississippi and Louisiana
- ✗Compounded only — no brand-name options
- ✗Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
NewSelf edges out Actin with a higher overall score of 7.8/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. Actin remains a solid alternative, especially if you're looking for affordable compounded semaglutide with B12 enhancement.
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