✓Expert Reviewed📅Updated April 2026🔒Independently Researched
PlushCare vs Sesame
An in-depth comparison of two leading GLP-1 Providers
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7.6
PlushCare
Best for mainstream telehealth GLP-1 accessStarting at $149/mo
CompoundedSemaglutideTirzepatide
Visit PlushCare →6.9
Sesame
Best for mainstream telehealth GLP-1 accessStarting at $199/mo
CompoundedSemaglutideTirzepatide
Visit Sesame →Side-by-Side Comparison
| Feature | PlushCare | Sesame |
|---|---|---|
| Overall Score | ✓7.6/10 | 6.9/10 |
| Starting Price | ✓$149/mo | $199/mo |
| Customer Rating | — | — |
| Features | 3 features | 3 features |
| States Available | 50 | 50 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
PlushCare
Pros
- ✓Aggressively low monthly pricing
- ✓Both semaglutide and tirzepatide available
- ✓Compounded GLP-1 access
Cons
- ✗Limited public information on program details
Sesame
Pros
- ✓Both semaglutide and tirzepatide available
- ✓Compounded GLP-1 access
Cons
- ✗Limited public information on program details
Our Verdict
Winner: PlushCareScore: 7.6/10
PlushCare edges out Sesame with a higher overall score of 7.6/10 and is particularly strong for mainstream telehealth GLP-1 access. Sesame remains a solid alternative, especially if you're looking for mainstream telehealth GLP-1 access.